• Judy Godec

Healing is a matter of time, but it is sometimes also a matter of opportunity.   -  Hippocrates


Greetings dear friends, A V&V client recently said of my, er... infrequent...newsletters, "No one could ever accuse you of sending out too many, but when you finally do, it's for a good reason!" This is one of those reasons. Since medical cannabis was legalized in the State of Colorado several years ago, I've been curious about the legal non-psychoactive component, CBD, and it’s beneficial effects for insomnia, pain, anxiety, and inflammation internally, and it's anti-aging and anti-inflammatory effects topically. I was initially skeptical about the use of cannabinoids as plant medicine. There are SO many manufacturers of topicals, tinctures etc. The first few products I sampled seemed very hit or miss - I couldn't tell if they were making a difference. I needed to find the highest quality, purest CBD in order to decide whether it belonged in V&V/Medicine Ranch's pharmacopeia. I researched countless cannabis companies and found the best of the best: a skilled, medical supplier with the most rigorous testing, and the cleanest, most potent product on the market with a track record of positive results. So exciting! They were more expensive, AND they were sold out. For a year.Though every other manufacturer seemed to have CBD coming out of their ears to sell, these folks couldn't keep up with demand. Hmmm, got to be a reason. We waited, and waited, and finally, in the past six months, we have been able to secure sufficient quantities from this superior quality formulator to keep up with our own growing demand. Internal CBD: What is it and what is it used for? Among the 60 or so cannabinoids present in cannabis, only THC is psychoactive. However, some of the other constituents, such as cannabidiol, have well-documented biological effects of potential therapeutic interest, such as antianxiety, anticonvulsive, anti-nausea, anti-inflammatory and antitumor properties. Primary among these, without delving too deeply in medical models, are CBD's ability to address pain, inflammation, anxiety, and insomnia. We have been selling internal CBD capsules for about six months and the results are nothing short of miraculous. If there is a magic bullet, for many people, this is it. Our CBD, as one client put it, makes her feel "more like herself." It exerts a calming, relaxing influence. It is pain relieving. It is a mild appetite suppressant. Our CBD capsules (10mg and 25mg dosages) are full-spectrum CBD, meaning they take advantage of all non-psychoactive compounds, providing an "entourage effect" of potency (the vast majority of CBD products are made with inexpensive (and ineffective) single isolate CBD - caveat emptor! I cannot tell you how many people have come into Medicine Ranch saying they already tried CBD and it didn't help. They take one of our capsules, and the next day they return to buy 500). Doses are measured, so you know exactly what you are taking (tinctures, syringes, and vape pens make dosing nearly impossible). The CBD is preservative, filler, additive, and solvent-free (most CBD products are solvent extracted - ew!). Dosage We recommend you start with 10mg, taken twice daily. If for sleep, start with 10mg before bed. If you don't feel anything, move to 20 or 25mg. Anything under 50mg is considered a microdose. Note: you can't take "too much." In other words, you won't get high (ever) no matter how much you take. Note: If you smoke weed, you will want to start with 25mg dose as you will already have a tolerance.

Shipping - Yes, it's Legal We can ship internal and topical CBD anywhere in the U.S.

Here is the link to the page for internal CBD capsules. Look for anything starting with "Broad Spectrum". You won't find a lot of information on the pages because Merchant Service Providers are still skittish about cannabis products.

https://www.venusandvetiver.com/tinctures-salves-energy-oils--the-lik Topical CBD: What is it and what is it used for? " Topicals", unlike many skin products, have the potential to be effective due to the large number of receptors on the surface of our skin. These receptors are part of our endocannabinoid system, which modulates physiological systems in the human body and brain. Like essential oils, CBD's bioavailability (ability to bind to receptors in therapeutically meaningful quantities) is the key to its effectiveness precisely because of its ability to penetrate the dermis (lightbulb moment !) Medicine Ranch CBD-infused products: - Argan EF Eye Therapy - Perfect Skin Scar Rx - Pure Love Cream - Joint and Inflammation Rx

- Superior Arnicopeia Oil I have links to dozens of peer reviewed articles from pubmed and scientific journals for a dozen or more of the systemic ailments that western medicine has not be able to touch including rheumatoid arthritis, cancer, weight loss, anxiety and depression, and many more. They are listed below, but I can't figure out how to make them links on this damn blog! Email me at judygodec@gmail.com if you want like any/all.

General

  • CBD as potential anticancer drug

  • CBD inhibits angiogenesis by multiple mechanisms

  • The inhibitory effects of CBD on systemic malignant tumors

  • CBD inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1

  • Marijuana fights cancer and helps manage side effects

  • In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma

  • The Influence of Biomechanical Properties and Cannabinoids on Tumor Invasion

  • Antitumorigenic targets of cannabinoids - current status and implications

  • Cannabinoids - a new weapon against cancer?

  • CBD, a novel inverse agonist for GPR12

Bladder

  • TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer

Brain

  • Cannabidiol enhances the inhibitory effects of delta9-THC on human glioblastoma cell proliferation and survival

  • Antitumor effects of CBD, a nonpsychoactive cannabinoid, on human glioma cell lines

  • Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas

  • CBD inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism

  • Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target

  • Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents

  • CBD inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect

  • Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme

  • Synergistic responses between cannabidiol and DNA-damaging agents on the proliferation and viability of glioblastoma and neural progenitor cells in culture

  • Cannabis improved survival of patients with aggressive brain cancer in controlled clinical study

Breast

  • Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma

  • CBD induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy

  • Pathways mediating the effects of CBD on the reduction of breast cancer cell proliferation, invasion, and metastasis

  • CBD as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells

  • Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration

  • CBD-A mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells

Colon

  • Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer

  • Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of CBD

  • Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent

Endocrine

  • Endocannabinoids in endocrine and related tumours

  • A comparative study on CBD-induced apoptosis in murine thymocytes and EL-4 thymoma cells

Kaposi Sarcoma

  • CBD inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium

Leukemia

  • CBD-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression

  • CBD-Induced Apoptosis in Human Leukemia Cells

  • Cannabidiol Reduces Leukemic Cell Size - But Is It Important?

Lung

  • CBD inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C

  • COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells

  • Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of CBD on human lung cancer cells

  • Media ignored expert’s shocking findings that marijuana helps prevent lung cancer

Pain

  • Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain

  • Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial

  • Marijuana extract helps prevent chemo pain

Prostate

  • Towards the use of non-psychoactive cannabinoids for prostate cancer

  • In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines

  • Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent

Skin

  • Anticancer activity of anandamide in human cutaneous melanoma cells

We are thrilled to be offering this valuable medicine to our clients. Please email with questions. In love, judy

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